Eaton P, Fuller W, Shattock MJ (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. J Biol Chem 277, 21189-96 11925435

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S45-p - CRYAB (rat) ▲

Modsite: FSTATSLsPFYLRPP SwissProt Entrez-Gene Orthologous residues CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  primary cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes H2O2 increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein H2O2 inhibit treatment-induced increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein decrease

S59-p - CRYAB (rat) ▲

Modsite: PSFLRAPsWIDTGLS SwissProt Entrez-Gene Orthologous residues CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  primary cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes H2O2 increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein H2O2 inhibit treatment-induced increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein decrease

S86-p - HSP27 (rat) ▲

Modsite: RALNRQLssGVsEIR SwissProt Entrez-Gene Orthologous residues HSP27 (human): S82‑p, HSP27 (mouse): S86‑p, HSP27 (rat): S86‑p, HSP27 (pig): S84‑p, HSP27 (hamster): S90‑p, HSP27 (chicken): S80‑p, HSP27 (dog): S86‑p, HSP27 (cow): S78‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes H2O2 increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein H2O2 inhibit treatment-induced increase SB203580, bisindolylmaleimide, PD98059, staurosporine, genistein decrease