Barrow AD, et al. (2004) Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J Immunol 172, 5838-42 15128762

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Y281-p - TREML1 (human) ▲

Modsite: VCSKPVTyATVIFPG SwissProt Entrez-Gene Orthologous residues TREML1 (human): Y281‑p, TREML1 (mouse): Y286‑p, TREML1 iso2 (mouse): Y291‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  leukemia Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil) Cellular systems studied:  cell lines Species studied:  rat Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  signaling pathway regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SHIP-2 (human) Induces intracellular localization co-immunoprecipitation Comments:  enhanced calcium signaling