Li N, et al. (2007) Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res 67, 11176-85 18056442

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S15-p - p53 (human) ▲

Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer, lung cancer, non-small cell lung cancer, fibrosarcoma of soft tissue Relevant cell lines - cell types - tissues:  L929 (fibroblast), MCF-7 (breast cell), NCI-H1299 (pulmonary) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  apoptosis, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PKHF1 (human) Induces co-immunoprecipitation

S18-p - p53 (mouse) ▲

Modsite: IsLELPLsQEtFsGL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer, lung cancer, non-small cell lung cancer, fibrosarcoma of soft tissue Relevant cell lines - cell types - tissues:  L929 (fibroblast), MCF-7 (breast cell), NCI-H1299 (pulmonary) Cellular systems studied:  cell lines Species studied:  human, mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase SB203580 TNF inhibit treatment-induced increase