Curated Information
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Home > Curated Information Page > PubMed Id: 24240237
Choi SH, et al. (2013) α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. Genes Dev 27, 2473-88 24240237
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y177-p - CTNNA1 (human)
Modsite: EQDLGIQykALkPEV SwissProt Entrez-Gene
Orthologous residues
CTNNA1 (human): Y177‑p, CTNNA1 iso2 (human): Y177‑p, CTNNA1 (mouse): Y177‑p, CTNNA1 (rat): Y177‑p, CTNNA1 (cow): Y177‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dasatinib decrease
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
APC (human) Disrupts co-immunoprecipitation
Comments:  enhances B-catenin transactivation

S33-p - CTNNB1 (human)
Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNA1 (human) increase siRNA decrease
APC (human) increase siRNA decrease

T120-p - CTNNB1 (human)
Modsite: QFdAAHPtNVQRLAE SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T120‑p, CTNNB1 (mouse): T120‑p, CTNNB1 (rat): T120‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Induces co-immunoprecipitation

Y142-p - CTNNB1 (human)
Modsite: AVVNLINyQDDAELA SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y142‑p, CTNNB1 (mouse): Y142‑p, CTNNB1 (rat): Y142‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Induces co-immunoprecipitation