Naik MU, Caplan JL, Naik UP (2014) Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c-Src complex. Blood 123, 1393-402 24300854

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y280-p - JAM-A (human) ▲

Modsite: tSsKkVIysQPsARs SwissProt Entrez-Gene Orthologous residues JAM‑A (human): Y280‑p, JAM‑A (mouse): Y281‑p, JAM‑A (rat): Y281‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  megakaryocyte Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CSK (human) SH2 Induces pull-down assay, co-immunoprecipitation

Y530-p - Src (human) ▲

Modsite: FTstEPQyQPGENL_ SwissProt Entrez-Gene Orthologous residues Src (human): Y530‑p, Src iso2 (human): Y536‑p, Src (mouse): Y529‑p, Src iso1 (mouse): Y535‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  platelet-blood Cellular systems studied:  primary cells Species studied:  human, mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CSK (human) co-immunoprecipitation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes BSA JAM-A (human) increase fibrinogen JAM-A (human) decrease Downstream Regulation Effect of modification (function):  enzymatic activity, induced