Curated Information
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Home > Curated Information Page > PubMed Id: 24990947
Dan HC, et al. (2014) Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα). J Biol Chem 289, 25227-40 24990947
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T23-p - IKKA (human)
Modsite: EMRERLGtGGFGNVC SwissProt Entrez-Gene
Orthologous residues
IKKA (human): T23‑p, IKKA (mouse): T23‑p, IKKA (rat): T23‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease

S1415-p - mTOR (human)
Modsite: PTPAILEsLIsINNK SwissProt Entrez-Gene
Orthologous residues
mTOR (human): S1415‑p, mTOR (mouse): S1415‑p, mTOR (rat): S1415‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKA (human)
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S1418-p - mTOR (human)
Modsite: AILEsLIsINNKLQQ SwissProt Entrez-Gene
Orthologous residues
mTOR (human): S1418‑p, mTOR (mouse): S1418‑p, mTOR (rat): S1418‑p

T412-p - p70S6K (human)
Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase