Curated Information
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Home > Curated Information Page > PubMed Id: 9452499
Yu Z, et al. (1998) SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 273, 3687-94 9452499
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) SH2 Induces signaling pathway regulation, transcription, inhibited co-immunoprecipitation

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) SH2 Induces co-immunoprecipitation

Y538-p - SHP-1 (rat)
Modsite: QRGQESEyGNITyPP SwissProt Entrez-Gene
Orthologous residues
SHP‑1 (human): Y536‑p, SHP‑1 iso2 (human): Y497‑p, SHP‑1 iso3 (human): Y538‑p, SHP‑1 iso4 (human): Y536‑p, SHP‑1 (mouse): Y536‑p, SHP‑1 (rat): Y538‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (rat) SH2 Induces in vitro, co-immunoprecipitation

Y543-p - SHP-1 (rat)
Modsite: SEyGNITyPPALRSA SwissProt Entrez-Gene
Orthologous residues
SHP‑1 (human): Y541‑p, SHP‑1 iso2 (human): Y502‑p, SHP‑1 iso3 (human): Y543‑p, SHP‑1 iso4 (human): Y541‑p, SHP‑1 (mouse): Y541‑p, SHP‑1 (rat): Y543‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (rat) SH2 Induces in vitro, co-immunoprecipitation