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Home > Curated Information Page > PubMed Id: 24970888
Meijles DN, Fan LM, Howlin BJ, Li JM (2014) Molecular Insights of p47phox Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production. J Biol Chem 289, 22759-70 24970888
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S303-p - p47phox (human)
Modsite: RGAPPRRssIRNAHs SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S303‑p, p47phox (mouse): S304‑p, p47phox (rat): S304‑p

S304-p - p47phox (human)
Modsite: GAPPRRssIRNAHsI SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S304‑p, p47phox (mouse): T305‑p, p47phox (rat): T305‑p

S310-p - p47phox (human)
Modsite: ssIRNAHsIHQRsRK SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S310‑p, p47phox (mouse): S311‑p, p47phox (rat): S311‑p

S315-p - p47phox (human)
Modsite: AHsIHQRsRKRLsQD SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S315‑p, p47phox (mouse): S316‑p, p47phox (rat): S316‑p

S320-p - p47phox (human)
Modsite: QRsRKRLsQDAYRRN SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S320‑p, p47phox (mouse): S321‑p, p47phox (rat): S321‑p

S328-p - p47phox (human)
Modsite: QDAYRRNsVRFLQQR SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S328‑p, p47phox (mouse): S329‑p, p47phox (rat): S329‑p

S345-p - p47phox (human)
Modsite: QARPGPQsPGsPLEE SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S345‑p, p47phox (mouse): S346‑p, p47phox (rat): S346‑p

S348-p - p47phox (human)
Modsite: PGPQsPGsPLEEERQ SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S348‑p, p47phox (mouse): G349‑p, p47phox (rat): S349‑p

S359-p - p47phox (human)
Modsite: EERQtQRsKPQPAVP SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S359‑p, p47phox (mouse): V359‑p, p47phox (rat): A358‑p

S370-p - p47phox (human)
Modsite: PAVPPRPsADLILNR SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S370‑p, p47phox (mouse): S370‑p, p47phox (rat): S369‑p

S379-p - p47phox (human)
Modsite: DLILNRCsEstKRKL SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S379‑p, p47phox (mouse): T379‑p, p47phox (rat): T378‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) SH3 Induces pull-down assay, in vitro
Comments:  induces instability of autoinhibitory region, increase O2 production