Curated Information
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Home > Curated Information Page > PubMed Id: 24958101
Siu KT, et al. (2014) Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired fbw7-mediated cyclin e regulation. Mol Cell Biol 34, 3244-58 24958101
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S15-p - p53 (human)
Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene
Orthologous residues
p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): , p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  thymocyte-thymus
Cellular systems studied:  tissue
Species studied:  mouse

T74-p - CCNE1 (mouse)
Modsite: DPCSFIPtPNKEEDN SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T77‑p, CCNE1 (mouse): T74‑p, CCNE1 (rat): T77‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  bone marrow, thymocyte-thymus
Cellular systems studied:  tissue
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Effect of modification (process):  cell cycle regulation
Comments:  using knock-in mutations impaired Fbw7-mediated degradation; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN)

T393-p - CCNE1 (mouse)
Modsite: PPPsVVLtPPPSSKK SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T395‑p, CCNE1 (mouse): T393‑p, CCNE1 (rat): T396‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  bone marrow, thymocyte-thymus
Cellular systems studied:  tissue
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Effect of modification (process):  cell cycle regulation
Comments:  using knock-in mutations impaired Fbw7-mediated degradation; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN)