Curated Information
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Home > Curated Information Page > PubMed Id: 24920628
Li L, Hasan R, Zhang X (2014) The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKCĪ²II. J Neurosci 34, 8246-58 24920628
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S502-p - TRPV1 (human)
Modsite: YFLQRRPsMKTLFVD SwissProt Entrez-Gene
Orthologous residues
TRPV1 (human): S502‑p, TRPV1 (mouse): S503‑p, TRPV1 (rat): S502‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  human, rat

T705-p - TRPV1 (human)
Modsite: WKLQRAItILDTEKS SwissProt Entrez-Gene
Orthologous residues
TRPV1 (human): T705‑p, TRPV1 (mouse): T705‑p, TRPV1 (rat): T704‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  human, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCB iso2 (human)
Downstream Regulation
Effect of modification (function):  activity, induced
Comments:  TRPV1 internalization, sensitivity to capsaicin, heat sensitivity

S801-p - TRPV1 (human)
Modsite: VPLLREAsARDRQsA SwissProt Entrez-Gene
Orthologous residues
TRPV1 (human): S801‑p, TRPV1 (mouse): S801‑p, TRPV1 (rat): S800‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  human, rat