Curated Information
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Home > Curated Information Page > PubMed Id: 23873023
Xu Y, et al. (2014) Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene 33, 3161-71 23873023
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T74-p - CCNE1 (mouse)
Modsite: DPCSFIPtPNKEEDN SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T77‑p, CCNE1 (mouse): T74‑p, CCNE1 (rat): T77‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  liver cancer, squamous cell carcinoma of the liver
Relevant cell lines - cell types - tissues:  'stem, hematopoietic', erythroblast-spleen, HSC (squamous)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  methylation, phosphorylation, protein degradation, ubiquitination
Effect of modification (process):  apoptosis, inhibited, cell cycle regulation, cell differentiation, induced, DNA repair, altered, transcription, altered
Comments:  Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9; regulation of oxidative metabolismand ROS production during terminal maturation

T393-p - CCNE1 (mouse)
Modsite: PPPsVVLtPPPSSKK SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T395‑p, CCNE1 (mouse): T393‑p, CCNE1 (rat): T396‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  liver cancer, squamous cell carcinoma of the liver
Relevant cell lines - cell types - tissues:  'stem, hematopoietic', erythroblast-spleen, HSC (squamous)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  methylation, phosphorylation, protein degradation, ubiquitination
Effect of modification (process):  apoptosis, inhibited, cell cycle regulation, cell differentiation, induced, DNA repair, altered, transcription, altered
Comments:  Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9; regulation of oxidative metabolismand ROS production during terminal maturation