Curated Information
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Home > Curated Information Page > PubMed Id: 11782464
Brandt SM, et al. (2002) Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem 277, 17291-9 11782464
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S336-p - CCR5 (human)
Modsite: QEAPERAssVyTRst SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S336‑p, CCR5 (mouse): S338‑p, CCR5 (rat): S338‑p
Characterization
Methods used to characterize site in vivo flow cytometry, mutation of modification site
Disease tissue studied:  lymphoma, anaplastic large cell lymphoma
Relevant cell lines - cell types - tissues:  CCRF-CEM (T lymphocyte), HOS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL3 increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

S337-p - CCR5 (human)
Modsite: EAPERAssVyTRstG SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S337‑p, CCR5 (mouse): S339‑p, CCR5 (rat): S339‑p
Characterization
Methods used to characterize site in vivo flow cytometry, mutation of modification site
Disease tissue studied:  lymphoma, anaplastic large cell lymphoma
Relevant cell lines - cell types - tissues:  CCRF-CEM (T lymphocyte), HOS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL3 increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

S342-p - CCR5 (human)
Modsite: AssVyTRstGEQEIs SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S342‑p, CCR5 (mouse): S344‑p, CCR5 (rat): S344‑p
Characterization
Methods used to characterize site in vivo flow cytometry, mutation of modification site
Disease tissue studied:  lymphoma, anaplastic large cell lymphoma
Relevant cell lines - cell types - tissues:  CCRF-CEM (T lymphocyte), HOS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL3 increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

S349-p - CCR5 (human)
Modsite: stGEQEIsVGL____ SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S349‑p, CCR5 (mouse): S351‑p, CCR5 (rat): S351‑p
Characterization
Methods used to characterize site in vivo flow cytometry, mutation of modification site
Disease tissue studied:  lymphoma, anaplastic large cell lymphoma
Relevant cell lines - cell types - tissues:  CCRF-CEM (T lymphocyte), HOS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL3 increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered