Curated Information
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Home > Curated Information Page > PubMed Id: 11713247
Coulpier M, Anders J, Ibáñez CF (2002) Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J Biol Chem 277, 1991-9 11713247
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y905-p - Ret (human)
Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): , Ret (rat): Y906‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  COS (fibroblast), MG87 (fibroblast), MN1 (neuron), Neuro-2a (neuron), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  chicken, green monkey, mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
ART increase
neurturin increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y1015-p - Ret (human)
Modsite: MMVKRRDyLDLAAST SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1015‑p, Ret iso2 (human): Y1015‑p, Ret iso3 (human): Y539‑p, Ret (mouse): Y1016‑p, Ret iso2 (mouse): Y1016‑p, Ret iso4 (mouse): , Ret (rat): Y1016‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  COS (fibroblast), MG87 (fibroblast), MN1 (neuron), Neuro-2a (neuron), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  chicken, green monkey, mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
ART increase
neurturin increase

Y1062-p - Ret (human)
Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): , Ret (rat): Y1063‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  COS (fibroblast), MG87 (fibroblast), MN1 (neuron), Neuro-2a (neuron), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  chicken, green monkey, mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
ART increase
neurturin increase

Y1096-p - Ret (human)
Modsite: RyPNDSVyANWMLSP SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1096‑p, Ret iso2 (human): , Ret iso3 (human): , Ret (mouse): Y1097‑p, Ret iso2 (mouse): , Ret iso4 (mouse): , Ret (rat): Y1097‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  COS (fibroblast), MG87 (fibroblast), MN1 (neuron), Neuro-2a (neuron), neuron-dorsal root ganglia
Cellular systems studied:  cell lines, primary cells
Species studied:  chicken, green monkey, mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
ART increase
neurturin increase