Curated Information
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Home > Curated Information Page > PubMed Id: 29115510
Kato T, Oka K, Nakamura T (2018) HGF induces the serine‑phosphorylation and cell surface translocation of ROMK (Kir 1.1) channels in rat kidney cells. Mol Med Rep 17, 1031-1034 29115510
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1235-p - Met (rat)
Modsite: RDMYDKEyySVHNKT SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1234‑p, Met iso2 (human): Y1252‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  NRK-52E (epithelial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase

Y1236-p - Met (rat)
Modsite: DMYDKEyySVHNKTG SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1235‑p, Met iso2 (human): Y1253‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  NRK-52E (epithelial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase

S44-p - ROMK (rat)
Modsite: RQRARLVsKEGRCNI SwissProt Entrez-Gene
Orthologous residues
ROMK (human): S44‑p, ROMK (mouse): S25‑p, ROMK (rat): S44‑p, ROMK iso2 (rat): S25‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  NRK-52E (epithelial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  translocates to the plasma membrane