Schweikhard ES, Kempson SA, Ziegler C, Burckhardt BC (2014) Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. Am J Physiol Renal Physiol 307, F107-15 24829506

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T40-p - SLC6A12 (dog) ▲

Modsite: VKDRGQWtNKMEFVL SwissProt Entrez-Gene Orthologous residues SLC6A12 (human): T40‑p, SLC6A12 (mouse): T40‑p, SLC6A12 iso2 (mouse): T54‑p, SLC6A12 (rat): T40‑p, SLC6A12 (dog): T40‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (human) co-immunoprecipitation, activation of upstream enzyme, phospho-antibody Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization Comments:  important for trafficking and insertion of SLC6A12 in the plasma membrane