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Home > Curated Information Page > PubMed Id: 24808538
Davies M, et al. (2014) Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK. Am J Physiol Renal Physiol 307, F96-F106 24808538
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T172-p - AMPKA2 (mouse)
Modsite: sDGEFLRtsCGsPNY SwissProt Entrez-Gene
Orthologous residues
AMPKA2 (human): T172‑p, AMPKA2 (mouse): T172‑p, AMPKA2 (rat): T172‑p, AMPKA2 (pig): T172‑p

T58-p - NCCT (mouse)
Modsite: MRtFGYNtIDVVPAY SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T60‑p, NCCT iso2 (human): T60‑p, NCCT iso3 (human): T60‑p, NCCT (mouse): T58‑p, NCCT (rat): T58‑p

T205-p - NKCC1 (mouse)
Modsite: TNtYYLRtFGHNtMD SwissProt Entrez-Gene
Orthologous residues
NKCC1 (human): T212‑p, NKCC1 iso3 (human): T212‑p, NKCC1 (mouse): T205‑p, NKCC1 (rat): T203‑p

T210-p - NKCC1 (mouse)
Modsite: LRtFGHNtMDAVPRI SwissProt Entrez-Gene
Orthologous residues
NKCC1 (human): T217‑p, NKCC1 iso3 (human): T217‑p, NKCC1 (mouse): T210‑p, NKCC1 (rat): T208‑p

T96-p - NKCC2 (mouse)
Modsite: TNtyyLQtFGHNtMD SwissProt Entrez-Gene
Orthologous residues
NKCC2 (human): T100‑p, NKCC2 (mouse): T96‑p, NKCC2 iso3 (mouse): , NKCC2 (rat): T96‑p, NKCC2 (rabbit): T99‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

T101-p - NKCC2 (mouse)
Modsite: LQtFGHNtMDAVPKI SwissProt Entrez-Gene
Orthologous residues
NKCC2 (human): T105‑p, NKCC2 (mouse): T101‑p, NKCC2 iso3 (mouse): T96‑p, NKCC2 (rat): T101‑p, NKCC2 (rabbit): T104‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

S126-p - NKCC2 (mouse)
Modsite: GPkVNRPsLLEIHEQ SwissProt Entrez-Gene
Orthologous residues
NKCC2 (human): S130‑p, NKCC2 (mouse): S126‑p, NKCC2 iso3 (mouse): S121‑p, NKCC2 (rat): S126‑p, NKCC2 (rabbit): S129‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

S325-p - OSR1 (mouse)
Modsite: VRRVPGssGRLHKtE SwissProt Entrez-Gene
Orthologous residues
OSR1 (human): S325‑p, OSR1 (mouse): S325‑p, OSR1 (rat): S325‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

S383-p - STLK3 (mouse)
Modsite: VRRVPGssGHLHKTE SwissProt Entrez-Gene
Orthologous residues
STLK3 (human): S371‑p, STLK3 (mouse): S383‑p, STLK3 (rat): S380‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase