Dong Q, et al. (2014) Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity. Biochem Biophys Res Commun 449, 449-54 24853806

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S331-p - SREBP-1 (rat) ▲

Modsite: AIEKRYRssINDKIV SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S337‑p, SREBP‑1 iso3 (human): S313‑p, SREBP‑1 iso4 (human): S367‑p, SREBP‑1 (mouse): S331‑p, SREBP‑1 iso4 (mouse): S265‑p, SREBP‑1 (rat): S331‑p, SREBP‑1 iso1 (rat): S307‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  E.coli (bacterial) Cellular systems studied:  cell lines Species studied:  bacteria Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human)

S332-p - SREBP-1 (rat) ▲

Modsite: IEKRYRssINDKIVE SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S338‑p, SREBP‑1 iso3 (human): S314‑p, SREBP‑1 iso4 (human): S368‑p, SREBP‑1 (mouse): S332‑p, SREBP‑1 iso4 (mouse): S266‑p, SREBP‑1 (rat): S332‑p, SREBP‑1 iso1 (rat): S308‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), E.coli (bacterial) Cellular systems studied:  cell lines Species studied:  bacteria, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Downstream Regulation Effect of modification (process):  transcription, inhibited

S308-p - SREBP-1 iso1 (rat) ▲

Modsite: IEKRYRSsINDKIVE SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S338‑p, SREBP‑1 iso3 (human): S314‑p, SREBP‑1 iso4 (human): S368‑p, SREBP‑1 (mouse): S332‑p, SREBP‑1 iso4 (mouse): S266‑p, SREBP‑1 (rat): S332‑p, SREBP‑1 iso1 (rat): S308‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, inhibited