Celver J, et al. (2004) Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol 65, 528-37 14978231

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T180-p - MOR-1 (rat) ▲

Modsite: VKALDFRtPRNAKIV SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T182‑p, MOR‑1 iso5 (human): T182‑p, MOR‑1 (mouse): T180‑p, MOR‑1 (rat): T180‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  AtT20 (pituitary cell) Cellular systems studied:  cell lines Species studied:  rat Downstream Regulation Effect of modification (function):  receptor desensitization, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays MOR-1 (rat) Not reported Comments:  Mutagenesis indicates T180 is required for receptor uncoupling, but phosphorylation of site has not been directly demonstrated.