Curated Information
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Home > Curated Information Page > PubMed Id: 24872409
Ong ST, et al. (2014) Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration. J Biol Chem 289, 19420-34 24872409
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T7-p - RAB5A (human)
Modsite: _MAsrGAtRPNGPNT SwissProt Entrez-Gene
Orthologous residues
RAB5A (human): T7‑p, RAB5A (mouse): T7‑p, RAB5A (rat): T7‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCE (human) pharmacological inhibitor of upstream enzyme, activation of upstream enzyme, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ICAM-1 increase
CXCL12 increase
phorbol_ester increase
bisindolylmaleimide ICAM-1 inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell motility, induced, cytoskeletal reorganization

S84-p - RAB5A (human)
Modsite: AGQERyHsLAPMYYR SwissProt Entrez-Gene
Orthologous residues
RAB5A (human): S84‑p, RAB5A (mouse): S84‑p, RAB5A (rat): S84‑p

S123-p - RAB5A (human)
Modsite: kELQRQAsPNIVIAL SwissProt Entrez-Gene
Orthologous residues
RAB5A (human): S123‑p, RAB5A (mouse): S123‑p, RAB5A (rat): S123‑p