Curated Information
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Home > Curated Information Page > PubMed Id: 14966296
Persson C, et al. (2004) Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol 24, 2190-201 14966296
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y578-p - PDGFRB (mouse)
Modsite: VssDGHEyIyVDPVQ SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y579‑p, PDGFRB (mouse): Y578‑p, PDGFRB (rat): Y578‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast), PAE (endothelial)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse, pig
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTPN2 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTP1B (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody
PHOSPHATASE PTPN2 (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y750-p - PDGFRB (mouse)
Modsite: SKDEsIDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPN2 (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y770-p - PDGFRB (mouse)
Modsite: ADIESPsyMAPyDNy SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPN2 (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y1020-p - PDGFRB (mouse)
Modsite: PNESDNDyIIPLPDP SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1021‑p, PDGFRB (mouse): Y1020‑p, PDGFRB (rat): Y1020‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast), PAE (endothelial)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse, pig
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTPN2 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPN2 (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase