Curated Information
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Home > Curated Information Page > PubMed Id: 24692544
Koraishy FM, et al. (2014) Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling. J Biol Chem 289, 14341-50 24692544
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S9-p - GSK3B (mouse)
Modsite: SGRPRttsFAEsCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p

Y216-p - GSK3B (mouse)
Modsite: RGEPNVsyICsRYYR SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p

S1490-p - LRP6 (mouse)
Modsite: AILNPPPsPAtERSH SwissProt Entrez-Gene
Orthologous residues
LRP6 (human): S1490‑p, LRP6 (mouse): S1490‑p, LRP6 (rat):
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase
CHIR99021 HGF inhibit treatment-induced increase
lithium HGF inhibit treatment-induced increase
Wnt3a increase

T1572-p - LRP6 (mouse)
Modsite: EPVPPPPtPRSQYLs SwissProt Entrez-Gene
Orthologous residues
LRP6 (human): T1572‑p, LRP6 (mouse): T1572‑p, LRP6 (rat):
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase
CHIR99021 HGF inhibit treatment-induced increase
lithium HGF inhibit treatment-induced increase
Wnt3a increase

S1607-p - LRP6 (mouse)
Modsite: HLYPPPPsPCTDSS_ SwissProt Entrez-Gene
Orthologous residues
LRP6 (human): S1607‑p, LRP6 (mouse): S1607‑p, LRP6 (rat):
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase
CHIR99021 HGF inhibit treatment-induced increase
lithium HGF inhibit treatment-induced increase
Wnt3a increase

S1234-p - Met (mouse)
Modsite: MyDKEyysVHNKtGA SwissProt Entrez-Gene
Orthologous residues
Met (human): S1236‑p, Met iso2 (human): S1254‑p, Met (mouse): S1234‑p, Met (rat): S1237‑p