Curated Information
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Home > Curated Information Page > PubMed Id: 29140246
Zhang H, et al. (2017) An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife 6 29140246
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T2122-p - Notch 1 (mouse)
Modsite: HGTALGGtPTLSPTL SwissProt Entrez-Gene
Orthologous residues
Notch 1 (human): T2132‑p, Notch 1 (mouse): T2122‑p, Notch 1 (rat): T2122‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE EYA1 (mouse)
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Effect of modification (process):  cell differentiation, inhibited