Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 29137318
Liang J, et al. (2017) miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway. Oncotarget 8, 82991-83008 29137318
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S9-p - GSK3B (human)
Modsite: SGRPRttsFAEsCkP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p

S1490-p - LRP6 (human)
Modsite: AILNPPPsPAtERsH SwissProt Entrez-Gene
Orthologous residues
LRP6 (human): S1490‑p, LRP6 (mouse): S1490‑p, LRP6 (rat): L1222‑p

S49-p - RXRA (human)
Modsite: GSPGQLHsPISTLSS SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S49‑p, RXRA (mouse): S54‑p, RXRA (rat): S54‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme, co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  ubiquitination
Comments:  negatively regulated beta-catenin expression by ubiquitination of ß-catenin in CRC

S66-p - RXRA (human)
Modsite: NGMGPPFsVISSPMG SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S66‑p, RXRA (mouse): S71‑p, RXRA (rat): S71‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme, co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  ubiquitination
Comments:  negatively regulated beta-catenin expression by ubiquitination of ß-catenin in CRC

S78-p - RXRA (human)
Modsite: PMGPHSMsVPTtPTL SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S78‑p, RXRA (mouse): S83‑p, RXRA (rat): S83‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme, co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  ubiquitination
Comments:  negatively regulated beta-catenin expression by ubiquitination of ß-catenin in CRC