Curated Information
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Home > Curated Information Page > PubMed Id: 29114038
Pyronneau A, et al. (2017) Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome. Sci Signal 10 29114038
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S3-p - Cofilin-1 (mouse)
Modsite: _____MAsGVAVsDG SwissProt Entrez-Gene
Orthologous residues
Cofilin‑1 (human): S3‑p, Cofilin‑1 (mouse): S3‑p, Cofilin‑1 (rat): S3‑p, Cofilin‑1 (pig): S3‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FMR1 (mouse) decrease FMR1 KO increase

T508-p - LIMK1 (mouse)
Modsite: PDRKKRYtVVGNPYW SwissProt Entrez-Gene
Orthologous residues
LIMK1 (human): T508‑p, LIMK1 (mouse): T508‑p, LIMK1 (rat): T508‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FMR1 (mouse) decrease FMR1 KO increase

S199-p - PAK1 (mouse)
Modsite: PRPEHTKsVYTRsVI SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): S199‑p, PAK1 (mouse): S199‑p, PAK1 (rat): S198‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FMR1 (mouse) decrease FMR1 KO increase
FMR1 (mouse) no change compared to control FMR1 KO no change

S476-p - PAK4 (mouse)
Modsite: KEVPRRKsLVGtPYW SwissProt Entrez-Gene
Orthologous residues
PAK4 (human): S474‑p, PAK4 iso2 (human): S309‑p, PAK4 (mouse): S476‑p, PAK4 (rat): S476‑p

S970-p - SSH1 (mouse)
Modsite: SPLKRSHsLAKLGSL SwissProt Entrez-Gene
Orthologous residues
SSH1 (human): S978‑p, SSH1 iso2 (human): , SSH1 iso4 (human): S666‑p, SSH1 (mouse): S970‑p, SSH1 (rat): S961‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FMR1 (mouse) decrease FMR1 KO increase