Curated Information
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Home > Curated Information Page > PubMed Id: 9482866
Innamorati G, Sadeghi HM, Tran NT, Birnbaumer M (1998) A serine cluster prevents recycling of the V2 vasopressin receptor. Proc Natl Acad Sci U S A 95, 2222-6 9482866
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S362-p - AVPR2 (human)
Modsite: DESCTTAsssLAKDT SwissProt Entrez-Gene
Orthologous residues
AVPR2 (human): S362‑p, AVPR2 (mouse): S362‑p, AVPR2 (rat): S362‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vasopressin increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface.

S363-p - AVPR2 (human)
Modsite: ESCTTAsssLAKDTS SwissProt Entrez-Gene
Orthologous residues
AVPR2 (human): S363‑p, AVPR2 (mouse): S363‑p, AVPR2 (rat): S363‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vasopressin increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface.

S364-p - AVPR2 (human)
Modsite: SCTTAsssLAKDTSS SwissProt Entrez-Gene
Orthologous residues
AVPR2 (human): S364‑p, AVPR2 (mouse): S364‑p, AVPR2 (rat): S364‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vasopressin increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface.