Lazari MF, et al. (1998) Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization. J Biol Chem 273, 18316-24 9660797

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S661-p - LHR (rat) ▲

Modsite: LYRRKEFsAYTsNCK SwissProt Entrez-Gene Orthologous residues LHR (human): S657‑p, LHR (mouse): S661‑p, LHR (rat): S661‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LH increase Downstream Regulation Effect of modification (function):  receptor internalization, altered Comments:  S661 is required for agonist-induced uncoupling and internalization.

S665-p - LHR (rat) ▲

Modsite: KEFsAYTsNCKNGFP SwissProt Entrez-Gene Orthologous residues LHR (human): S661‑p, LHR (mouse): F665‑p, LHR (rat): S665‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LH increase Downstream Regulation Effect of modification (function):  receptor internalization, altered Comments:  S665 is required for agonist-induced uncoupling and internalization.

S675-p - LHR (rat) ▲

Modsite: KNGFPGAsKPsQATL SwissProt Entrez-Gene Orthologous residues LHR (human): N671‑p, LHR (mouse): S675‑p, LHR (rat): S675‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LH increase Downstream Regulation Effect of modification (function):  receptor internalization, altered Comments:  S675 is essential for agonist-induced internalization but not for agonist-induced uncoupling.

S678-p - LHR (rat) ▲
Modsite: FPGAsKPsQATLKLS SwissProt Entrez-Gene Orthologous residues LHR (human): S674‑p, LHR (mouse): S678‑p, LHR (rat): S678‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human