Curated Information
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Home > Curated Information Page > PubMed Id: 9660797
Lazari MF, et al. (1998) Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization. J Biol Chem 273, 18316-24 9660797
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S661-p - LHR (rat)
Modsite: LYRRKEFsAYTsNCK SwissProt Entrez-Gene
Orthologous residues
LHR (human): S657‑p, LHR (mouse): S661‑p, LHR (rat): S661‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LH increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered
Comments:  S661 is required for agonist-induced uncoupling and internalization.

S665-p - LHR (rat)
Modsite: KEFsAYTsNCKNGFP SwissProt Entrez-Gene
Orthologous residues
LHR (human): S661‑p, LHR (mouse): F665‑p, LHR (rat): S665‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LH increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered
Comments:  S665 is required for agonist-induced uncoupling and internalization.

S675-p - LHR (rat)
Modsite: KNGFPGAsKPsQATL SwissProt Entrez-Gene
Orthologous residues
LHR (human): N671‑p, LHR (mouse): S675‑p, LHR (rat): S675‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LH increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered
Comments:  S675 is essential for agonist-induced internalization but not for agonist-induced uncoupling.

S678-p - LHR (rat)
Modsite: FPGAsKPsQATLKLS SwissProt Entrez-Gene
Orthologous residues
LHR (human): S674‑p, LHR (mouse): S678‑p, LHR (rat): S678‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human