Curated Information
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Home > Curated Information Page > PubMed Id: 14766744
Encinas M, Crowder RJ, Milbrandt J, Johnson EM (2004) Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. J Biol Chem 279, 18262-9 14766744
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y981-p - Ret (human)
Modsite: DNCSEEMyRLMLQCW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y981‑p, Ret iso2 (human): Y981‑p, Ret iso3 (human): Y505‑p, Ret (mouse): Y982‑p, Ret iso2 (mouse): Y982‑p, Ret iso4 (mouse): , Ret (rat): Y982‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Ret (human) transfection of wild-type enzyme, transfection of dominant-negative enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Src (human) Induces enzymatic activity, induced co-immunoprecipitation

Y1015-p - Ret (human)
Modsite: MMVKRRDyLDLAAST SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1015‑p, Ret iso2 (human): Y1015‑p, Ret iso3 (human): Y539‑p, Ret (mouse): Y1016‑p, Ret iso2 (mouse): Y1016‑p, Ret iso4 (mouse): , Ret (rat): Y1016‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase

Y1029-p - Ret (human)
Modsite: TPSDSLIyDDGLSEE SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1029‑p, Ret iso2 (human): Y1029‑p, Ret iso3 (human): Y553‑p, Ret (mouse): Y1030‑p, Ret iso2 (mouse): Y1030‑p, Ret iso4 (mouse): , Ret (rat): Y1030‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase