Nagy G, et al. (2004) Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron 41, 417-29 14766180

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T138-p - SNAP-25 (mouse) ▲

Modsite: GGFIRRVtNDARENE SwissProt Entrez-Gene Orthologous residues SNAP‑25 (human): T138‑p, SNAP‑25 iso2 (human): T138‑p, SNAP‑25 (mouse): T138‑p, SNAP‑25 (rat): T138‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (mouse) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase IBMX increase cAMP_analog increase KT5720 decrease

T138-p - SNAP-25 (rat) ▲

Modsite: GGFIRRVtNDARENE SwissProt Entrez-Gene Orthologous residues SNAP‑25 (human): T138‑p, SNAP‑25 iso2 (human): T138‑p, SNAP‑25 (mouse): T138‑p, SNAP‑25 (rat): T138‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  chromaffin-adrenal gland Cellular systems studied:  primary cultured cells Species studied:  cow Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (cow) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase IBMX increase cAMP_analog increase KT5720 decrease Downstream Regulation Comments:  regulates exocytosis