Smyth EM, Li WH, FitzGerald GA (1998) Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. J Biol Chem 273, 23258-66 9722557

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S328-p - PTGIR (human) ▲

Modsite: TPLSQLAsGRRDPRA SwissProt Entrez-Gene Orthologous residues PTGIR (human): S328‑p, PTGIR (mouse): S355‑p, PTGIR (rat): S356‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (rat) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (rat) pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester increase iloprost increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered Comments:  S328A mutant had markedly reduced level of desensitization