Fontes MS, et al. (2014) Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy. PLoS One 9, e87226 24498049

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S364-p - GJA1 (mouse) ▲

Modsite: AIVDQRPssRAssRA SwissProt Entrez-Gene Orthologous residues GJA1 (human): S364‑p, GJA1 (mouse): S364‑p, GJA1 (rat): S364‑p, GJA1 (rabbit): S364‑p, GJA1 (pig): S364‑p, GJA1 (hamster): S364‑p, GJA1 (cow): S365‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'heart, ventricle' Cellular systems studied:  primary cultured cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP3CB (mouse)

S365-p - GJA1 (mouse) ▲

Modsite: IVDQRPssRAssRAs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'heart, ventricle' Cellular systems studied:  primary cultured cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP3CB (mouse)

S368-p - GJA1 (mouse) ▲

Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'heart, ventricle' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FK506 increase Downstream Regulation Effect of modification (function):  protein stabilization Associated Diseases Diseases Alterations Comments hypertrophic cardiomyopathy decreased