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Home > Curated Information Page > PubMed Id: 24637012
Karaki S, et al. (2014) Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists. Mol Cell Proteomics 13, 1273-85 24637012
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S280-p - 5-HT(2A) (human)
Modsite: GTRAKLAsFSFLPQs SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S280‑p, 5‑HT(2A) (mouse): S280‑p, 5‑HT(2A) (rat): S280‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase
DOI increase
NPC-15437 DOI inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, induced

S287-p - 5-HT(2A) (human)
Modsite: sFSFLPQssLssEKL SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S287‑p, 5‑HT(2A) (mouse): S287‑p, 5‑HT(2A) (rat): S287‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S288-p - 5-HT(2A) (human)
Modsite: FSFLPQssLssEKLF SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S288‑p, 5‑HT(2A) (mouse): S288‑p, 5‑HT(2A) (rat): S288‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase

S290-p - 5-HT(2A) (human)
Modsite: FLPQssLssEKLFQR SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S290‑p, 5‑HT(2A) (mouse): S290‑p, 5‑HT(2A) (rat): S290‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S291-p - 5-HT(2A) (human)
Modsite: LPQssLssEKLFQRs SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S291‑p, 5‑HT(2A) (mouse): S291‑p, 5‑HT(2A) (rat): S291‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase

S298-p - 5-HT(2A) (human)
Modsite: sEKLFQRsIHREPGs SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S298‑p, 5‑HT(2A) (mouse): S298‑p, 5‑HT(2A) (rat): S298‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride increase

S305-p - 5-HT(2A) (human)
Modsite: sIHREPGsYTGRRTM SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S305‑p, 5‑HT(2A) (mouse): S305‑p, 5‑HT(2A) (rat): S305‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S339-p - AKAP8 (human)
Modsite: DAAGDFRsGDEEFKG SwissProt Entrez-Gene
Orthologous residues
AKAP8 (human): S339‑p, AKAP8 (mouse): S336‑p, AKAP8 (rat): S337‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

T945-p - ARHGEF2 (human)
Modsite: QDssDPDtGsEEEGs SwissProt Entrez-Gene
Orthologous residues
ARHGEF2 (human): T945‑p, ARHGEF2 iso2 (human): T944‑p, ARHGEF2 iso3 (human): T917‑p, ARHGEF2 (mouse): T944‑p, ARHGEF2 (rat): T944‑p, ARHGEF2 (pig): T919‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S956-p - ARHGEF2 (human)
Modsite: EEGssRLsPPHsPRD SwissProt Entrez-Gene
Orthologous residues
ARHGEF2 (human): S956‑p, ARHGEF2 iso2 (human): S955‑p, ARHGEF2 iso3 (human): S928‑p, ARHGEF2 (mouse): S955‑p, ARHGEF2 (rat): S955‑p, ARHGEF2 (pig): S931‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S960-p - ARHGEF2 (human)
Modsite: sRLsPPHsPRDFTRM SwissProt Entrez-Gene
Orthologous residues
ARHGEF2 (human): S960‑p, ARHGEF2 iso2 (human): S959‑p, ARHGEF2 iso3 (human): S932‑p, ARHGEF2 (mouse): S959‑p, ARHGEF2 (rat): S959‑p, ARHGEF2 (pig): S935‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S828-p - ATG9A (human)
Modsite: EPVPEEGsEDELPPQ SwissProt Entrez-Gene
Orthologous residues
ATG9A (human): S828‑p, ATG9A (mouse): , ATG9A iso2 (mouse): S828‑p, ATG9A (rat): S828‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S301-p - BRD2 (human)
Modsite: LAPGsPAsPPGsLEP SwissProt Entrez-Gene
Orthologous residues
BRD2 (human): S301‑p, BRD2 iso2 (human): S301‑p, BRD2 (mouse): S300‑p, BRD2 (rat): S300‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S655-p - BUB1 (human)
Modsite: PSRDGkFsPIQEksP SwissProt Entrez-Gene
Orthologous residues
BUB1 (human): S655‑p, BUB1 (mouse): G641‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S661-p - BUB1 (human)
Modsite: FsPIQEksPkQALss SwissProt Entrez-Gene
Orthologous residues
BUB1 (human): S661‑p, BUB1 (mouse):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S447-p - Cortactin (human)
Modsite: tEPEPVysMEAADyR SwissProt Entrez-Gene
Orthologous residues
Cortactin (human): S447‑p, Cortactin iso2 (human): S410‑p, Cortactin iso3 (human): S410‑p, Cortactin (mouse): S443‑p, Cortactin (rat): S405‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S182-p - FAM90A26 (human)
Modsite: DRGSALAsLsPLRKA SwissProt Entrez-Gene
Orthologous residues
FAM90A26 (human): S182‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease
DOI decrease

S184-p - FAM90A26 (human)
Modsite: GSALAsLsPLRKASL SwissProt Entrez-Gene
Orthologous residues
FAM90A26 (human): S184‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease
DOI decrease

S100-p - GATAD2A (human)
Modsite: kSERRPPsPDVIVLs SwissProt Entrez-Gene
Orthologous residues
GATAD2A (human): S100‑p, GATAD2A iso2 (human): S100‑p, GATAD2A iso3 (human): S100‑p, GATAD2A (mouse): S96‑p, GATAD2A (rat): S96‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S107-p - GATAD2A (human)
Modsite: sPDVIVLsDNEQPss SwissProt Entrez-Gene
Orthologous residues
GATAD2A (human): S107‑p, GATAD2A iso2 (human): S107‑p, GATAD2A iso3 (human): S107‑p, GATAD2A (mouse): S103‑p, GATAD2A (rat): S103‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S113-p - GATAD2A (human)
Modsite: LsDNEQPssPRVNGL SwissProt Entrez-Gene
Orthologous residues
GATAD2A (human): S113‑p, GATAD2A iso2 (human): S113‑p, GATAD2A iso3 (human): S113‑p, GATAD2A (mouse): S109‑p, GATAD2A (rat): S109‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S369-p - HDGF2 (human)
Modsite: AERGsGGssGDELRE SwissProt Entrez-Gene
Orthologous residues
HDGF2 (human): S369‑p, HDGF2 iso2 (human): S369‑p, HDGF2 (mouse): S366‑p, HDGF2 iso2 (mouse): S365‑p, HDGF2 iso3 (mouse): S375‑p, HDGF2 (rat): S366‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride increase

S370-p - HDGF2 (human)
Modsite: ERGsGGssGDELRED SwissProt Entrez-Gene
Orthologous residues
HDGF2 (human): S370‑p, HDGF2 iso2 (human): S370‑p, HDGF2 (mouse): S367‑p, HDGF2 iso2 (mouse): S366‑p, HDGF2 iso3 (mouse): S376‑p, HDGF2 (rat): S367‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride increase

S75-p - HIP (human)
Modsite: DLKADEPssEEsDLE SwissProt Entrez-Gene
Orthologous residues
HIP (human): S75‑p, HIP (mouse): S74‑p, HIP (rat): S74‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S76-p - HIP (human)
Modsite: LKADEPssEEsDLEI SwissProt Entrez-Gene
Orthologous residues
HIP (human): S76‑p, HIP (mouse): S75‑p, HIP (rat): S75‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S79-p - HIP (human)
Modsite: DEPssEEsDLEIDKE SwissProt Entrez-Gene
Orthologous residues
HIP (human): S79‑p, HIP (mouse): S78‑p, HIP (rat): S78‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S1231-p - IRS4 (human)
Modsite: RPPEREDsDNDDDtH SwissProt Entrez-Gene
Orthologous residues
IRS4 (human): S1231‑p, IRS4 (mouse): S1193‑p, IRS4 (rat): S1205‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S628-p - KRI1 (human)
Modsite: GsLMGPEsPPAQEEE SwissProt Entrez-Gene
Orthologous residues
KRI1 (human): S628‑p, KRI1 (mouse): T632‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S639-p - KRI1 (human)
Modsite: QEEEAPVsPHKKPAP SwissProt Entrez-Gene
Orthologous residues
KRI1 (human): S639‑p, KRI1 (mouse): S644‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S13-p - LYN (human)
Modsite: SKGkDsLsDDGVDLk SwissProt Entrez-Gene
Orthologous residues
LYN (human): S13‑p, LYN iso2 (human): S13‑p, LYN (mouse): N13‑p, LYN iso2 (mouse): N13‑p, LYN (rat): N13‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S1915-p - MAP1B (human)
Modsite: kIERttksPsDsGys SwissProt Entrez-Gene
Orthologous residues
MAP1B (human): S1915‑p, MAP1B (mouse): S1911‑p, MAP1B (rat): S1906‑p, MAP1B (cow): S1910‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S90-p - MKK4 (human)
Modsite: SSGkLkIsPEQHWDF SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): S90‑p, MKK4 iso2 (human): S101‑p, MKK4 (mouse): S88‑p, MKK4 (rat): S88‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S332-p - NDRG2 (human)
Modsite: LsRsRtAsLtsAAsV SwissProt Entrez-Gene
Orthologous residues
NDRG2 (human): S332‑p, NDRG2 iso2 (human): S318‑p, NDRG2 (mouse): S332‑p, NDRG2 (rat): S332‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S338-p - NDRG2 (human)
Modsite: AsLtsAAsVDGNRsR SwissProt Entrez-Gene
Orthologous residues
NDRG2 (human): S338‑p, NDRG2 iso2 (human): S324‑p, NDRG2 (mouse): S338‑p, NDRG2 (rat): S338‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S1386-p - NHSL1 (human)
Modsite: DDHsRNHsPsPPVtP SwissProt Entrez-Gene
Orthologous residues
NHSL1 (human): S1386‑p, NHSL1 iso2 (human): S1382‑p, NHSL1 (mouse): S1373‑p, NHSL1 iso3 (mouse): S1369‑p, NHSL1 (rat): S1228‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S1388-p - NHSL1 (human)
Modsite: HsRNHsPsPPVtPtG SwissProt Entrez-Gene
Orthologous residues
NHSL1 (human): S1388‑p, NHSL1 iso2 (human): S1384‑p, NHSL1 (mouse): S1375‑p, NHSL1 iso3 (mouse): S1371‑p, NHSL1 (rat): S1230‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

T607-p - NOLC1 (human)
Modsite: AkKIkLQtPNtFPKR SwissProt Entrez-Gene
Orthologous residues
NOLC1 (human): T607‑p, NOLC1 iso2 (human): T617‑p, NOLC1 iso3 (human): T608‑p, NOLC1 (mouse): T610‑p, NOLC1 (rat): T612‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

T610-p - NOLC1 (human)
Modsite: IkLQtPNtFPKRKKG SwissProt Entrez-Gene
Orthologous residues
NOLC1 (human): T610‑p, NOLC1 iso2 (human): T620‑p, NOLC1 iso3 (human): T611‑p, NOLC1 (mouse): T613‑p, NOLC1 (rat): T615‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S116-p - PEA-15 (human)
Modsite: kDIIRQPsEEEIIKL SwissProt Entrez-Gene
Orthologous residues
PEA‑15 (human): S116‑p, PEA‑15 (mouse): S116‑p, PEA‑15 (rat): S116‑p, PEA‑15 (hamster): S116‑p, PEA‑15 (cow): S116‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S903-p - PLEKHA7 (human)
Modsite: PQLRKVtsPLQsPtK SwissProt Entrez-Gene
Orthologous residues
PLEKHA7 (human): S903‑p, PLEKHA7 iso2 (human): S903‑p, PLEKHA7 iso5 (human): S903‑p, PLEKHA7 (mouse): S900‑p, PLEKHA7 iso2 (mouse): S900‑p, PLEKHA7 (rat): S900‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S907-p - PLEKHA7 (human)
Modsite: KVtsPLQsPtKAKPK SwissProt Entrez-Gene
Orthologous residues
PLEKHA7 (human): S907‑p, PLEKHA7 iso2 (human): S907‑p, PLEKHA7 iso5 (human): S907‑p, PLEKHA7 (mouse): S904‑p, PLEKHA7 iso2 (mouse): S904‑p, PLEKHA7 (rat): S904‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S530-p - PML (human)
Modsite: DGPPsPRsPVIGsEV SwissProt Entrez-Gene
Orthologous residues
PML (human): S530‑p, PML iso2 (human): S530‑p, PML iso3 (human): S530‑p, PML iso4 (human): S530‑p, PML iso5 (human): S530‑p, PML iso8 (human): S530‑p, PML iso10 (human): , PML iso11 (human): S482‑p, PML iso12 (human): S482‑p, PML iso14 (human): , PML (mouse): S540‑p, PML iso2 (mouse): S494‑p, PML (rat): S528‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease
DOI decrease

S88-p - PRAS40 (human)
Modsite: PPAPQPPsPtPsPPR SwissProt Entrez-Gene
Orthologous residues
PRAS40 (human): S88‑p, PRAS40 iso2 (human): , PRAS40 iso3 (human): S108‑p, PRAS40 (mouse): S88‑p, PRAS40 (rat): S88‑p, PRAS40 (cow): S88‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S92-p - PRAS40 (human)
Modsite: QPPsPtPsPPRPtLA SwissProt Entrez-Gene
Orthologous residues
PRAS40 (human): S92‑p, PRAS40 iso2 (human): , PRAS40 iso3 (human): S112‑p, PRAS40 (mouse): S92‑p, PRAS40 (rat): S92‑p, PRAS40 (cow): S92‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S807-p - Rb (human)
Modsite: PGGNIyIsPLksPyk SwissProt Entrez-Gene
Orthologous residues
Rb (human): S807‑p, Rb (mouse): S800‑p, Rb (rat): S799‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S811-p - Rb (human)
Modsite: IyIsPLksPykIsEG SwissProt Entrez-Gene
Orthologous residues
Rb (human): S811‑p, Rb (mouse): S804‑p, Rb (rat): S803‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S149-p - RBM23 (human)
Modsite: sPHFREKsPVREPVD SwissProt Entrez-Gene
Orthologous residues
RBM23 (human): S149‑p, RBM23 iso2 (human): S133‑p, RBM23 iso4 (human):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S20-p - RRM2 (human)
Modsite: DPQQLQLsPLkGLsL SwissProt Entrez-Gene
Orthologous residues
RRM2 (human): S20‑p, RRM2 iso2 (human): S80‑p, RRM2 (mouse): S20‑p, RRM2 (rat): S20‑p, RRM2 (cow): S17‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S2481-p - SHARP (human)
Modsite: sVTAAKLsPPVAsGG SwissProt Entrez-Gene
Orthologous residues
SHARP (human): S2481‑p, SHARP (mouse): P2479‑p, SHARP (rat): P2447‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S2493-p - SHARP (human)
Modsite: sGGIPHQsPPTkVTE SwissProt Entrez-Gene
Orthologous residues
SHARP (human): S2493‑p, SHARP (mouse): S2491‑p, SHARP (rat): S2459‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S22-p - SMC4 (human)
Modsite: EEGPPPPsPDGAssD SwissProt Entrez-Gene
Orthologous residues
SMC4 (human): S22‑p, SMC4 iso2 (human): S22‑p, SMC4 (mouse): S21‑p, SMC4 (rat): S21‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S27-p - SMC4 (human)
Modsite: PPsPDGAssDAEPEP SwissProt Entrez-Gene
Orthologous residues
SMC4 (human): S27‑p, SMC4 iso2 (human): S27‑p, SMC4 (mouse): H26‑p, SMC4 (rat): L26‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

T1003-p - SRm300 (human)
Modsite: yPkVKAQtPPGPsLs SwissProt Entrez-Gene
Orthologous residues
SRm300 (human): T1003‑p, SRm300 iso2 (human): T1003‑p, SRm300 (mouse): T973‑p, SRm300 iso2 (mouse): T877‑p, SRm300 iso3 (mouse): T973‑p, SRm300 (rat): T975‑p, SRm300 (cow): T983‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S1014-p - SRm300 (human)
Modsite: PsLsGsKsPCPQEKs SwissProt Entrez-Gene
Orthologous residues
SRm300 (human): S1014‑p, SRm300 iso2 (human): S1014‑p, SRm300 (mouse): S984‑p, SRm300 iso2 (mouse): S888‑p, SRm300 iso3 (mouse): S984‑p, SRm300 (rat): S986‑p, SRm300 (cow): S993‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S616-p - TAT-SF1 (human)
Modsite: KVLDEEGsEREFDED SwissProt Entrez-Gene
Orthologous residues
TAT‑SF1 (human): S616‑p, TAT‑SF1 (mouse): S613‑p, TAT‑SF1 (rat): S631‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S624-p - TAT-SF1 (human)
Modsite: EREFDEDsDEKEEEE SwissProt Entrez-Gene
Orthologous residues
TAT‑SF1 (human): S624‑p, TAT‑SF1 (mouse): S621‑p, TAT‑SF1 (rat): S639‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S176-p - TPD52 (human)
Modsite: kNsPtFksFEEkVEN SwissProt Entrez-Gene
Orthologous residues
TPD52 (human): S176‑p, TPD52 iso2 (human): S136‑p, TPD52 iso4 (human): S159‑p, TPD52 iso5 (human): S190‑p, TPD52 iso6 (human): S199‑p, TPD52 iso7 (human): S185‑p, TPD52 (mouse): S175‑p, TPD52 iso4 (mouse): S198‑p, TPD52 iso5 (mouse): S145‑p, TPD52 (rat): S175‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase

S166-p - TPD52L2 (human)
Modsite: RNsAtFksFEDrVGt SwissProt Entrez-Gene
Orthologous residues
TPD52L2 (human): S166‑p, TPD52L2 iso2 (human): S146‑p, TPD52L2 iso3 (human): S169‑p, TPD52L2 iso4 (human): S160‑p, TPD52L2 iso5 (human): S180‑p, TPD52L2 iso7 (human): S189‑p, TPD52L2 (mouse): S180‑p, TPD52L2 iso2 (mouse): S146‑p, TPD52L2 iso3 (mouse): S189‑p, TPD52L2 iso4 (mouse): S180‑p, TPD52L2 (rat): S180‑p, TPD52L2 (cow): S189‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S686-p - TRAPPC11 (human)
Modsite: GKKIEITsVDLALGN SwissProt Entrez-Gene
Orthologous residues
TRAPPC11 (human): S686‑p, TRAPPC11 (mouse): S686‑p, TRAPPC11 (rat): S804‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase

T695-p - TRAPPC11 (human)
Modsite: DLALGNEtGRCVVLN SwissProt Entrez-Gene
Orthologous residues
TRAPPC11 (human): T695‑p, TRAPPC11 (mouse): S695‑p, TRAPPC11 (rat): S813‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase

S1263-p - TRRAP (human)
Modsite: VRKQAMHsLQVLAQV SwissProt Entrez-Gene
Orthologous residues
TRRAP (human): S1263‑p, TRRAP iso4 (human): S977‑p, TRRAP (mouse): , TRRAP iso3 (mouse): S1263‑p, TRRAP (rat): S1264‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride increase
DOI increase

T1271-p - TRRAP (human)
Modsite: LQVLAQVtGKSVTVI SwissProt Entrez-Gene
Orthologous residues
TRRAP (human): T1271‑p, TRRAP iso4 (human): T985‑p, TRRAP (mouse): , TRRAP iso3 (mouse): T1271‑p, TRRAP (rat): T1272‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride increase
DOI increase

S16-p - TSPYL2 (human)
Modsite: PAkTRRLsssEsPQR SwissProt Entrez-Gene
Orthologous residues
TSPYL2 (human): S16‑p, TSPYL2 (mouse): S16‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S20-p - TSPYL2 (human)
Modsite: RRLsssEsPQRDPPP SwissProt Entrez-Gene
Orthologous residues
TSPYL2 (human): S20‑p, TSPYL2 (mouse): P20‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S810-p - UBE1 (human)
Modsite: sGVkIHVsDQELQsA SwissProt Entrez-Gene
Orthologous residues
UBE1 (human): S810‑p, UBE1 (mouse): S810‑p, UBE1 (rat): S810‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S13-p - UGP2 (human)
Modsite: QDLSkAMsQDGASQF SwissProt Entrez-Gene
Orthologous residues
UGP2 (human): S13‑p, UGP2 iso2 (human): S2‑p, UGP2 (mouse): S13‑p, UGP2 (rat): S13‑p, UGP2 (cow): S13‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S447-p - XRCC1 (human)
Modsite: tQAAGPssPQKPPtP SwissProt Entrez-Gene
Orthologous residues
XRCC1 (human): S447‑p, XRCC1 (mouse): S446‑p, XRCC1 (rat): S446‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

T453-p - XRCC1 (human)
Modsite: ssPQKPPtPEEtKAA SwissProt Entrez-Gene
Orthologous residues
XRCC1 (human): T453‑p, XRCC1 (mouse): T452‑p, XRCC1 (rat): T452‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S97-p - ZNF768 (human)
Modsite: sPGLVPPsPEFAPRs SwissProt Entrez-Gene
Orthologous residues
ZNF768 (human): S97‑p, ZNF768 (mouse): S100‑p, ZNF768 (rat): S99‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated

S308-p - ZNF828 (human)
Modsite: rRPAPAVsPGsWKPG SwissProt Entrez-Gene
Orthologous residues
ZNF828 (human): S308‑p, ZNF828 (mouse): S298‑p, ZNF828 (rat): S298‑p, ZNF828 (cow): S311‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S319-p - ZNF828 (human)
Modsite: WKPGPPGsPRPWKsN SwissProt Entrez-Gene
Orthologous residues
ZNF828 (human): S319‑p, ZNF828 (mouse): S309‑p, ZNF828 (rat): S309‑p, ZNF828 (cow): S322‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial), 293 (epithelial) [5-HT(2A) (human), transfection]
Cellular systems studied:  cell lines
Species studied:  human
Comments:  DOI treated, lisuride treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI decrease

S382-p - ZNF828 (human)
Modsite: VsPssWKsPPAsPEs SwissProt Entrez-Gene
Orthologous residues
ZNF828 (human): S382‑p, ZNF828 (mouse): T371‑p, ZNF828 (rat): T371‑p, ZNF828 (cow): S374‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S386-p - ZNF828 (human)
Modsite: sWKsPPAsPEsWksG SwissProt Entrez-Gene
Orthologous residues
ZNF828 (human): S386‑p, ZNF828 (mouse): S375‑p, ZNF828 (rat): S375‑p, ZNF828 (cow): S378‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lisuride decrease

S280-p - 5-HT(2A) (mouse)
Modsite: sTRAkLSsFSFLPQS SwissProt Entrez-Gene
Orthologous residues
5‑HT(2A) (human): S280‑p, 5‑HT(2A) (mouse): S280‑p, 5‑HT(2A) (rat): S280‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DOI increase
lisuride no change compared to control