Curated Information
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Home > Curated Information Page > PubMed Id: 24616519
Mitrea DM, et al. (2014) Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc Natl Acad Sci U S A 111, 4466-71 24616519
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S48-p - NPM1 (mouse)
Modsite: QLsLRTVsLGAGAkD SwissProt Entrez-Gene
Orthologous residues
NPM1 (human): S48‑p, NPM1 iso2 (human): S48‑p, NPM1 iso3 (human): S48‑p, NPM1 (mouse): S48‑p, NPM1 (rat): S48‑p, NPM1 iso2 (rat): S48‑p
Characterization
Methods used to characterize site in vivo 2D analysis, [32P] ATP in vitro, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  protein conformation

S88-p - NPM1 (mouse)
Modsite: MsVQPTVsLGGFEIt SwissProt Entrez-Gene
Orthologous residues
NPM1 (human): S88‑p, NPM1 iso2 (human): S88‑p, NPM1 iso3 (human): S88‑p, NPM1 (mouse): S88‑p, NPM1 (rat): S88‑p, NPM1 iso2 (rat): S88‑p
Characterization
Methods used to characterize site in vivo 2D analysis, [32P] ATP in vitro, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  protein conformation

T95-p - NPM1 (mouse)
Modsite: sLGGFEItPPVVLRL SwissProt Entrez-Gene
Orthologous residues
NPM1 (human): T95‑p, NPM1 iso2 (human): T95‑p, NPM1 iso3 (human): T95‑p, NPM1 (mouse): T95‑p, NPM1 (rat): T95‑p, NPM1 iso2 (rat): T95‑p
Characterization
Methods used to characterize site in vivo 2D analysis, [32P] ATP in vitro, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  protein conformation

S125-p - NPM1 (mouse)
Modsite: AVEEDAEsEDEDEED SwissProt Entrez-Gene
Orthologous residues
NPM1 (human): S125‑p, NPM1 iso2 (human): S125‑p, NPM1 iso3 (human): S125‑p, NPM1 (mouse): S125‑p, NPM1 (rat): S125‑p, NPM1 iso2 (rat): S125‑p
Characterization
Methods used to characterize site in vivo 2D analysis, [32P] ATP in vitro, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  protein conformation