Curated Information
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Home > Curated Information Page > PubMed Id: 24522204
Bavelloni A, et al. (2014) Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells. FASEB J 28, 2009-19 24522204
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S91-p - BAP37 (human)
Modsite: RARPRkIssPTGSkD SwissProt Entrez-Gene
Orthologous residues
BAP37 (human): S91‑p, BAP37 iso2 (human): S91‑p, BAP37 (mouse): S91‑p, BAP37 (rat): S91‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  leukemia, acute myelogenous leukemia
Relevant cell lines - cell types - tissues:  293 (epithelial), NB-4 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE Akt2 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
KINASE Akt1 (human) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S176-p - BAP37 (human)
Modsite: TERAKDFsLILDDVA SwissProt Entrez-Gene
Orthologous residues
BAP37 (human): S176‑p, BAP37 iso2 (human): S176‑p, BAP37 (mouse): S176‑p, BAP37 (rat): S176‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  leukemia, acute myelogenous leukemia
Relevant cell lines - cell types - tissues:  293 (epithelial), NB-4 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt2 (human)
KINASE Akt1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
KINASE Akt1 (human) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T55-p - CBX3 (human)
Modsite: FLkWkGFtDADNtWE SwissProt Entrez-Gene
Orthologous residues
CBX3 (human): T55‑p, CBX3 (mouse): T55‑p, CBX3 (rat): T55‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T89-p - CBX3 (human)
Modsite: AGkEkDGtKRksLsD SwissProt Entrez-Gene
Orthologous residues
CBX3 (human): T89‑p, CBX3 (mouse): T89‑p, CBX3 (rat): T89‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S36-p - H2B2F (human)
Modsite: RKRsRkEsysVyVyk SwissProt Entrez-Gene
Orthologous residues
H2B2F (human): S36‑p, H2B2F iso2 (human): S36‑p, H2B2F (rat):
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S36-p - HIST1H2BJ (human)
Modsite: RKRSRkEsysIyVyk SwissProt Entrez-Gene
Orthologous residues
HIST1H2BJ (human): S36‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T45-p - HIST2H3A/C/D (human)
Modsite: PHryrPGtVALrEIR SwissProt Entrez-Gene
Orthologous residues
HIST2H3A/C/D (human): T45‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S168-p - RBM8A (human)
Modsite: GGRRRsRsPDRRRR_ SwissProt Entrez-Gene
Orthologous residues
RBM8A (human): S168‑p, RBM8A iso2 (human): S167‑p, RBM8A (mouse): S168‑p, RBM8A iso2 (mouse): S167‑p, RBM8A (rat): S168‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S106-p - RPL13 (human)
Modsite: DPrRRNkstEsLQAN SwissProt Entrez-Gene
Orthologous residues
RPL13 (human): S106‑p, RPL13 (mouse): S106‑p, RPL13 (rat): S106‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T106-p - RPL7A (human)
Modsite: AHkYRPEtkQEKKQR SwissProt Entrez-Gene
Orthologous residues
RPL7A (human): T106‑p, RPL7A (mouse): T106‑p, RPL7A (rat): T106‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T70-p - RPS3 (human)
Modsite: GrrIrELtAVVQkRF SwissProt Entrez-Gene
Orthologous residues
RPS3 (human): T70‑p, RPS3 (mouse): T70‑p, RPS3 (rat): T70‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T10-p - RPS3A (human)
Modsite: VGKNKRLtKGGKKGA SwissProt Entrez-Gene
Orthologous residues
RPS3A (human): T10‑p, RPS3A (mouse): T10‑p, RPS3A (rat): T10‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

T88-p - RPS3A (human)
Modsite: FRkFkLItEDVQGkN SwissProt Entrez-Gene
Orthologous residues
RPS3A (human): T88‑p, RPS3A (mouse): T88‑p, RPS3A (rat): T88‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S112-p - RPS3A (human)
Modsite: LTRDkMCsMVKKWQT SwissProt Entrez-Gene
Orthologous residues
RPS3A (human): S112‑p, RPS3A (mouse): S112‑p, RPS3A (rat): S112‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S236-p - S6 (human)
Modsite: AKRRRLssLRAstsK SwissProt Entrez-Gene
Orthologous residues
S6 (human): S236‑p, S6 (mouse): S236‑p, S6 (rat): S236‑p, S6 (fruit fly): S235‑p, S6 (cow): S236‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S122-p - SFRS3 (human)
Modsite: SPRRRsFsRsRsRsL SwissProt Entrez-Gene
Orthologous residues
SFRS3 (human): S122‑p, SFRS3 (mouse): S122‑p, SFRS3 (rat): S122‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) co-immunoprecipitation
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S128-p - SFRS3 (human)
Modsite: FsRsRsRsLsRDRRR SwissProt Entrez-Gene
Orthologous residues
SFRS3 (human): S128‑p, SFRS3 (mouse): S128‑p, SFRS3 (rat): S128‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) co-immunoprecipitation
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S130-p - SFRS3 (human)
Modsite: RsRsRsLsRDRRRER SwissProt Entrez-Gene
Orthologous residues
SFRS3 (human): S130‑p, SFRS3 (mouse): S130‑p, SFRS3 (rat): S130‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) co-immunoprecipitation
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S138-p - SFRS3 (human)
Modsite: RDRRRERsLsRERNH SwissProt Entrez-Gene
Orthologous residues
SFRS3 (human): S138‑p, SFRS3 (mouse): S138‑p, SFRS3 (rat): S138‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
KINASE Akt1 (human) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S140-p - SFRS3 (human)
Modsite: RRRERsLsRERNHKP SwissProt Entrez-Gene
Orthologous residues
SFRS3 (human): S140‑p, SFRS3 (mouse): S140‑p, SFRS3 (rat): S140‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) co-immunoprecipitation
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase

S48-p - VDAC2 (human)
Modsite: DVKtksCsGVEFSts SwissProt Entrez-Gene
Orthologous residues
VDAC2 (human): S48‑p, VDAC2 iso1 (human): S63‑p, VDAC2 iso2 (human): S37‑p, VDAC2 (mouse): S49‑p, VDAC2 (rat): S49‑p, VDAC2 (pig): S48‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
retinoic_acid increase