Curated Information
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Home > Curated Information Page > PubMed Id: 24405715
Kakade D, Islam N, Maeda N, Adegoke OA (2014) Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes. BMC Cell Biol 15, 2 24405715
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T389-p - p70S6K iso2 (rat)
Modsite: NQVFLGFtYVAPSVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  L6 (myoblast)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum_starvation no change compared to control
refeeding increase 2h
rapamycin refeeding inhibit treatment-induced increase
refeeding increase 3h
rapamycin refeeding inhibit treatment-induced increase

S67-p - PDCD4 (rat)
Modsite: KRRLRKNsSRDSGRG SwissProt Entrez-Gene
Orthologous residues
PDCD4 (human): S67‑p, PDCD4 iso2 (human): S56‑p, PDCD4 (mouse): S67‑p, PDCD4 (rat): S67‑p, PDCD4 (cow): S67‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  L6 (myoblast)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum_starvation no change compared to control
refeeding increase 2h
rapamycin refeeding inhibit treatment-induced increase
refeeding no change compared to control 3h
rapamycin no change compared to control

S457-p - PDCD4 (rat)
Modsite: RGRKRFVsEGDGGRL SwissProt Entrez-Gene
Orthologous residues
PDCD4 (human): S457‑p, PDCD4 iso2 (human): S446‑p, PDCD4 (mouse): S457‑p, PDCD4 (rat): S457‑p, PDCD4 (cow): S457‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  L6 (myoblast)
Cellular systems studied:  cell lines
Species studied:  rat