Curated Information
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Home > Curated Information Page > PubMed Id: 9821957
Marmiroli S, et al. (1998) Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. FEBS Lett 438, 49-54 9821957
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y496-p - IL-1RA (human)
Modsite: ELEKIQDyEKMPESI SwissProt Entrez-Gene
Orthologous residues
IL‑1RA (human): Y496‑p, IL‑1RA (mouse): Y499‑p, IL‑1RA (rat): Y499‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  Saos-2 (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-1b increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces activity, induced co-immunoprecipitation