Gresko E, Möller A, Roscic A, Schmitz ML (2005) Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability. Biochem Biophys Res Commun 329, 1293-9 15766567

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K32-sm - HIPK2 (human) ▲

Modsite: FCSVKKLkIEPSSNW SwissProt Entrez-Gene Orthologous residues HIPK2 (human): K32‑sm, HIPK2 (mouse): K32‑sm, HIPK2 (rat): K32‑sm Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme SUMO LIGASE UBC9 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes SUMO LIGASE UBC9 (human) transfection of wild-type enzyme Downstream Regulation Effect of modification (function):  protein degradation