Mascle XH, et al. (2007) Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain. J Biol Chem 282, 10190-202 17298944

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K554-sm - TIF1B (mouse) ▲

Modsite: LPGMAIVkEEETEAA SwissProt Entrez-Gene Orthologous residues TIF1B (human): K554‑sm, TIF1B iso2 (human): K472‑sm, TIF1B (mouse): K554‑sm, TIF1B (rat): K555‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme Downstream Regulation Effect of modification (process):  transcription, inhibited

K575-sm - TIF1B (mouse) ▲

Modsite: APEGPETkPVLMPLT SwissProt Entrez-Gene Orthologous residues TIF1B (human): K575‑sm, TIF1B iso2 (human): K493‑sm, TIF1B (mouse): K575‑sm, TIF1B (rat): K576‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif Downstream Regulation Effect of modification (process):  transcription, inhibited

K676-sm - TIF1B (mouse) ▲

Modsite: CHVLPDLkEEDGsLs SwissProt Entrez-Gene Orthologous residues TIF1B (human): K676‑sm, TIF1B iso2 (human): K594‑sm, TIF1B (mouse): K676‑sm, TIF1B (rat): K677‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme Downstream Regulation Effect of modification (process):  transcription, inhibited

K750-sm - TIF1B (mouse) ▲

Modsite: IRARLQEkLsPPyss SwissProt Entrez-Gene Orthologous residues TIF1B (human): K750‑sm, TIF1B iso2 (human): K668‑sm, TIF1B (mouse): K750‑sm, TIF1B (rat): K751‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif Downstream Regulation Effect of modification (process):  transcription, inhibited

K779-sm - TIF1B (mouse) ▲

Modsite: FNkLTEDkADVQsII SwissProt Entrez-Gene Orthologous residues TIF1B (human): K779‑sm, TIF1B iso2 (human): K697‑sm, TIF1B (mouse): K779‑sm, TIF1B (rat): K780‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme Downstream Regulation Effect of modification (process):  transcription, inhibited

K804-sm - TIF1B (mouse) ▲

Modsite: NDAFGDTkFSAVLVE SwissProt Entrez-Gene Orthologous residues TIF1B (human): K804‑sm, TIF1B iso2 (human): K722‑sm, TIF1B (mouse): K804‑sm, TIF1B (rat): K805‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DESUMOYLASE SENP1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme SUMO LIGASE PIAS4 (mouse) transfection of wild-type enzyme, modification site within consensus motif Downstream Regulation Effect of modification (process):  transcription, inhibited