Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 10744745
Bae YS, et al. (2000) Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem 275, 10527-31 10744745
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF inhibit treatment-induced increase Y to F mutations decrease H2O2 production as copared to wild-type
LY294002 PDGF inhibit treatment-induced increase
PDGF inhibit treatment-induced increase Y to F mutation H2O2 production compared to wildtype
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compared to wild-type
PIK3C2A (human) increase membrane asociated p110 PI3K
LY294002 PIK3C2A (human) inhibit treatment-induced increase
wortmannin PIK3C2A (human) inhibit treatment-induced increase
PDGF increase
PDGF RAC1 (human) inhibit treatment-induced increase Dominant negative Rac1 -effect on H2O2 production
PDGF no effect upon treatment-induced increase Y to F mutation H2O2 production comapred to wild-type

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF inhibit treatment-induced increase Y to F mutations decrease H2O2 production as copared to wild-type
LY294002 PDGF inhibit treatment-induced increase
PDGF inhibit treatment-induced increase Y to F mutation H2O2 production compared to wildtype
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compared to wild-type
PIK3C2A (human) increase membrane asociated p110 PI3K
LY294002 PIK3C2A (human) inhibit treatment-induced increase
wortmannin PIK3C2A (human) inhibit treatment-induced increase
PDGF increase
PDGF RAC1 (human) inhibit treatment-induced increase Dominant negative Rac1 -effect on H2O2 production
PDGF no effect upon treatment-induced increase Y to F mutation H2O2 production comapred to wild-type

Y771-p - PDGFRB (human)
Modsite: ADIESSNyMAPyDNy SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF inhibit treatment-induced increase Y to F mutations decrease H2O2 production as copared to wild-type
LY294002 PDGF inhibit treatment-induced increase
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compared to wild-type
PIK3C2A (human) increase membrane asociated p110 PI3K
LY294002 PIK3C2A (human) inhibit treatment-induced increase
wortmannin PIK3C2A (human) inhibit treatment-induced increase
PDGF increase
PDGF RAC1 (human) inhibit treatment-induced increase Dominant negative Rac1 -effect on H2O2 production
PDGF inhibit treatment-induced increase Y to F mutation H2O2 production compared to wildtype
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compard to wild-type
PDGF no effect upon treatment-induced increase Y to F mutation H2O2 production comapred to wild-type

Y1009-p - PDGFRB (human)
Modsite: LDTSSVLyTAVQPNE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1009‑p, PDGFRB (mouse): Y1008‑p, PDGFRB (rat): Y1008‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF inhibit treatment-induced increase Y to F mutations decrease H2O2 production as copared to wild-type
LY294002 PDGF inhibit treatment-induced increase
PIK3C2A (human) increase membrane asociated p110 PI3K
LY294002 PIK3C2A (human) inhibit treatment-induced increase
wortmannin PIK3C2A (human) inhibit treatment-induced increase
PDGF increase
PDGF RAC1 (human) inhibit treatment-induced increase Dominant negative Rac1 -effect on H2O2 production
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compard to wild-type
PDGF no effect upon treatment-induced increase Y to F mutation H2O2 production comapred to wild-type

Y1021-p - PDGFRB (human)
Modsite: PNEGDNDyIIPLPDP SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1021‑p, PDGFRB (mouse): Y1020‑p, PDGFRB (rat): Y1020‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
PDGF inhibit treatment-induced increase Y to F mutations decrease H2O2 production as copared to wild-type
LY294002 PDGF inhibit treatment-induced increase
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PDGF no effect upon treatment-induced increase H2O2 production compared to wild-type
PIK3C2A (human) increase membrane asociated p110 PI3K
LY294002 PIK3C2A (human) inhibit treatment-induced increase
wortmannin PIK3C2A (human) inhibit treatment-induced increase
PDGF increase
PDGF RAC1 (human) inhibit treatment-induced increase Dominant negative Rac1 -effect on H2O2 production
PDGF inhibit treatment-induced increase Y to F mutation -H2O2 production compard to wild-type