Curated Information
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Home > Curated Information Page > PubMed Id: 10514456
Maestes DC, Potter RM, Prossnitz ER (1999) Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J Biol Chem 274, 29791-5 10514456
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S328-p - FPR1 (human)
Modsite: ERALtEDstQtsDtA SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): S328‑p, FPR1 (mouse): S339‑p, FPR1 (rat): S332‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T329-p - FPR1 (human)
Modsite: RALtEDstQtsDtAt SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): T329‑p, FPR1 (mouse): A340‑p, FPR1 (rat): A333‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T331-p - FPR1 (human)
Modsite: LtEDstQtsDtAtNs SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): T331‑p, FPR1 (mouse): T342‑p, FPR1 (rat): T335‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S332-p - FPR1 (human)
Modsite: tEDstQtsDtAtNst SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): S332‑p, FPR1 (mouse): S343‑p, FPR1 (rat): S336‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T334-p - FPR1 (human)
Modsite: DstQtsDtAtNstLP SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): T334‑p, FPR1 (mouse): T345‑p, FPR1 (rat): T338‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T336-p - FPR1 (human)
Modsite: tQtsDtAtNstLPsA SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): T336‑p, FPR1 (mouse): T347‑p, FPR1 (rat): T340‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S338-p - FPR1 (human)
Modsite: tsDtAtNstLPsAEV SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): S338‑p, FPR1 (mouse): L349‑p, FPR1 (rat): L342‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T339-p - FPR1 (human)
Modsite: sDtAtNstLPsAEVE SwissProt Entrez-Gene
Orthologous residues
FPR1 (human): T339‑p, FPR1 (mouse): G350‑p, FPR1 (rat): G343‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fMLP increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered