Gupta MP, Kogut P, Gupta M (2000) Protein kinase-A dependent phosphorylation of transcription enhancer factor-1 represses its DNA-binding activity but enhances its gene activation ability. Nucleic Acids Res 28, 3168-77 10931933

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S102-p - TEAD1 (mouse) ▲

Modsite: QVLARRKsRDFHSKL SwissProt Entrez-Gene Orthologous residues TEAD1 (human): S102‑p, TEAD1 iso2 (human): S87‑p, TEAD1 (mouse): S102‑p, TEAD1 (rat): S87‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  Sol8 (myoblast) Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (mouse) transfection of wild-type enzyme Downstream Regulation Comments:  TEF1 phosphorylation at S102 reduces its DNA-binding activity; plays a role in the PKA-dependent activation of the alpha-MHC gene expression.