Curated Information
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Home > Curated Information Page > PubMed Id: 24161395
Li Y, et al. (2013) Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis. Biochem Biophys Res Commun 441, 661-7 24161395
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K310-ac - NFkB-p65 (human)
Modsite: KRtyEtFksIMkksP SwissProt Entrez-Gene
Orthologous residues
NFkB‑p65 (human): K310‑ac, NFkB‑p65 (mouse): K310‑ac, NFkB‑p65 (rat): K310‑ac
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site, western blotting
Disease tissue studied:  brain cancer, astrocytoma, glioblastoma, glioblastoma multiforme, glioma
Relevant cell lines - cell types - tissues:  A172 (glial), CCF-STTG1 (glial), T98G (glial), U-251 MG (glial), U87MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
DEACETYLASE SIRT2 (human) transfection of inactive enzyme, siRNA inhibition of enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AGK2 increase
siRNA increase SIRT2 siRNA
AK1 increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  apoptosis, inhibited, carcinogenesis, induced, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays