Curated Information
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Home > Curated Information Page > PubMed Id: 14711813
Kawamoto Y, et al. (2004) Identification of RET autophosphorylation sites by mass spectrometry. J Biol Chem 279, 14213-24 14711813
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y806-p - Ret (human)
Modsite: PLLLIVEyAKyGSLR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y806‑p, Ret iso2 (human): Y806‑p, Ret iso3 (human): Y330‑p, Ret (mouse): Y807‑p, Ret iso2 (mouse): Y807‑p, Ret iso4 (mouse): Y756‑p, Ret (rat): Y807‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell growth, altered

Y809-p - Ret (human)
Modsite: LIVEyAKyGSLRGFL SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y809‑p, Ret iso2 (human): Y809‑p, Ret iso3 (human): Y333‑p, Ret (mouse): Y810‑p, Ret iso2 (mouse): Y810‑p, Ret iso4 (mouse): Y759‑p, Ret (rat): Y810‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell growth, altered

Y900-p - Ret (human)
Modsite: FGLSRDVyEEDsyVK SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y900‑p, Ret iso2 (human): Y900‑p, Ret iso3 (human): Y424‑p, Ret (mouse): Y901‑p, Ret iso2 (mouse): Y901‑p, Ret iso4 (mouse): , Ret (rat): Y901‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y905-p - Ret (human)
Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): , Ret (rat): Y906‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Ret (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell growth, altered

Y981-p - Ret (human)
Modsite: DNCSEEMyRLMLQCW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y981‑p, Ret iso2 (human): Y981‑p, Ret iso3 (human): Y505‑p, Ret (mouse): Y982‑p, Ret iso2 (mouse): Y982‑p, Ret iso4 (mouse): , Ret (rat): Y982‑p

Y1062-p - Ret (human)
Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): , Ret (rat): Y1063‑p

Y1090-p - Ret (human)
Modsite: TNTGFPRyPNDSVyA SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1090‑p, Ret iso2 (human): , Ret iso3 (human): , Ret (mouse): Y1091‑p, Ret iso2 (mouse): , Ret iso4 (mouse): , Ret (rat): Y1091‑p

Y1096-p - Ret (human)
Modsite: RyPNDSVyANWMLSP SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1096‑p, Ret iso2 (human): , Ret iso3 (human): , Ret (mouse): Y1097‑p, Ret iso2 (mouse): , Ret iso4 (mouse): , Ret (rat): Y1097‑p