Curated Information
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Home > Curated Information Page > PubMed Id: 12972574
Ferjoux G, et al. (2003) Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation. Mol Biol Cell 14, 3911-28 12972574
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y228-p - SSTR2 (mouse)
Modsite: LTIICLCyLFIIIKV SwissProt Entrez-Gene
Orthologous residues
SSTR2 (human): Y228‑p, SSTR2 (mouse): Y228‑p, SSTR2 (rat): Y228‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey, hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vapreotide SSTR2 (mouse) increase in the presence of RC-160 phosphorylation of this site increased in the first 30 sec but later gradually decreased
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (mouse) Induces co-immunoprecipitation, plasmon resonance, in vitro

Y312-p - SSTR2 (mouse)
Modsite: SCANPILyAFLSDNF SwissProt Entrez-Gene
Orthologous residues
SSTR2 (human): Y312‑p, SSTR2 (mouse): Y312‑p, SSTR2 (rat): Y312‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey, hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vapreotide SSTR2 (mouse) increase in the presence of RC-160 phosphorylation of this site increased in the first 30 sec but later gradually decreased
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (mouse) Induces co-immunoprecipitation, plasmon resonance, in vitro