Godin-Heymann N, Wang Y, Slee E, Lu X (2013) Phosphorylation of ASPP2 by RAS/MAPK Pathway Is Critical for Its Full Pro-Apoptotic Function. PLoS One 8, e82022 24312625

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S827-p - 53BP2 (human) ▲

Modsite: NSDMPAPsPGLDYEP SwissProt Entrez-Gene Orthologous residues 53BP2 (human): S827‑p, 53BP2 iso3 (human): S833‑p, 53BP2 (mouse): S827‑p, 53BP2 (rat): P827‑p, 53BP2 (cow): S833‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, western blotting Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  Saos-2 (bone cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK2 (human) Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  apoptosis, induced, transcription, induced Comments:  necessary for Ras-induced translocation to the cytosol and nucleus, p53 mediated transcription and pro-apoptotic activity