Williams G, et al. (2013) Transcriptional basis for the inhibition of neural stem cell proliferation and migration by the TGFβ-family member GDF11. PLoS One 8, e78478 24244313

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S465-p - SMAD2 (human) ▲

Modsite: sPsVRCssMs_____ SwissProt Entrez-Gene Orthologous residues SMAD2 (human): S465‑p, SMAD2 (mouse): S465‑p, SMAD2 (rat): S465‑p, SMAD2 (cow): S465‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  Cor-1 Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GDF11 (human) increase soluble GDF11 MSTN (human) GDF11 (human) inhibit treatment-induced increase soluble MSTN EGF, FGF2 no change compared to control

S467-p - SMAD2 (human) ▲

Modsite: sVRCssMs_______ SwissProt Entrez-Gene Orthologous residues SMAD2 (human): S467‑p, SMAD2 (mouse): S467‑p, SMAD2 (rat): S467‑p, SMAD2 (cow): S467‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  Cor-1 Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GDF11 (human) increase soluble GDF11 MSTN (human) GDF11 (human) inhibit treatment-induced increase soluble MSTN EGF, FGF2 no change compared to control

S423-p - SMAD3 (human) ▲

Modsite: sPsIRCssVs_____ SwissProt Entrez-Gene Orthologous residues SMAD3 (human): S423‑p, SMAD3 (mouse): S423‑p, SMAD3 (rat): S423‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  Cor-1 Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GDF11 (human) increase soluble GDF11 MSTN (human) GDF11 (human) inhibit treatment-induced increase soluble MSTN EGF, FGF2 no change compared to control

S425-p - SMAD3 (human) ▲

Modsite: sIRCssVs_______ SwissProt Entrez-Gene Orthologous residues SMAD3 (human): S425‑p, SMAD3 (mouse): S425‑p, SMAD3 (rat): S425‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  Cor-1 Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GDF11 (human) increase soluble GDF11 MSTN (human) GDF11 (human) inhibit treatment-induced increase soluble MSTN EGF, FGF2 no change compared to control