Mahankali M, Henkels KM, Gomez-Cambronero J (2013) A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration. J Cell Sci 126, 1416-28 23378025

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Y415-p - PLD2 (human) ▲

Modsite: ALGINSGysKRALML SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y415‑p, PLD2 (mouse): Y415‑p, PLD2 (rat): Y415‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), neutrophil-blood Cellular systems studied:  cell lines Species studied:  green monkey, human Downstream Regulation Effect of modification (process):  cell motility, induced Comments:  activates lipase activity and inhibits GEF activity