Luu W, et al. (2014) Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. J Lipid Res 55, 410-20 24363437

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T110-p - Diminuto (human) ▲

Modsite: RVGKYKKtHKNIMIN SwissProt Entrez-Gene Orthologous residues Diminuto (human): T110‑p, Diminuto iso2 (human): T69‑p, Diminuto (mouse): T110‑p, Diminuto (rat): T110‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y299-p - Diminuto (human) ▲

Modsite: KLNSIGNyykPWFFK SwissProt Entrez-Gene Orthologous residues Diminuto (human): Y299‑p, Diminuto iso2 (human): Y258‑p, Diminuto (mouse): Y299‑p, Diminuto (rat): Y299‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Downstream Regulation Effect of modification (function):  enzymatic activity, induced, protein stabilization

Y300-p - Diminuto (human) ▲

Modsite: LNSIGNyykPWFFKH SwissProt Entrez-Gene Orthologous residues Diminuto (human): Y300‑p, Diminuto iso2 (human): Y259‑p, Diminuto (mouse): Y300‑p, Diminuto (rat): Y300‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Downstream Regulation Effect of modification (function):  protein stabilization

Y507-p - Diminuto (human) ▲

Modsite: QDAFPEVyDkICkAA SwissProt Entrez-Gene Orthologous residues Diminuto (human): Y507‑p, Diminuto iso2 (human): Y466‑p, Diminuto (mouse): Y507‑p, Diminuto (rat): Y507‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Downstream Regulation Effect of modification (function):  enzymatic activity, induced

T202-p - ERK1 (human) ▲

Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene Orthologous residues ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vanadate increase

Y204-p - ERK1 (human) ▲

Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene Orthologous residues ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vanadate increase

T185-p - ERK2 (human) ▲

Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene Orthologous residues ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vanadate increase

Y187-p - ERK2 (human) ▲

Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene Orthologous residues ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vanadate increase