Curated Information
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Home > Curated Information Page > PubMed Id: 24223520
Liu C, et al. (2013) N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol 11, e1001704 24223520
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y253-p - N-WASP (mouse)
Modsite: RETSKVIyDFIEKTG SwissProt Entrez-Gene
Orthologous residues
N‑WASP (human): Y256‑p, N‑WASP (mouse): Y253‑p, N‑WASP (rat): Y253‑p, N‑WASP (cow): Y256‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  cytoskeletal reorganization

Y293-p - WASP (mouse)
Modsite: AETsKLIyDFIEDQG SwissProt Entrez-Gene
Orthologous residues
WASP (human): Y291‑p, WASP (mouse): Y293‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  cytoskeletal reorganization

S501-p - WASP (mouse)
Modsite: KRSRVIHssDEGEDQ SwissProt Entrez-Gene
Orthologous residues
WASP (human): S483‑p, WASP (mouse): S501‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  cytoskeletal reorganization

S502-p - WASP (mouse)
Modsite: RSRVIHssDEGEDQT SwissProt Entrez-Gene
Orthologous residues
WASP (human): S484‑p, WASP (mouse): S502‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  cytoskeletal reorganization