Curated Information
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Home > Curated Information Page > PubMed Id: 12809555
Adams RA, Liu X, Williams DS, Newton AC (2003) Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J 374, 537-43 12809555
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S334-p - Rhodopsin (mouse)
Modsite: PLGDDDAsATAsKtE SwissProt Entrez-Gene
Orthologous residues
Rhodopsin (human): S334‑p, Rhodopsin (mouse): S334‑p, Rhodopsin (rat): S334‑p, Rhodopsin (cow): S334‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  placental-retina
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
light increase
phorbol_ester increase

S338-p - Rhodopsin (mouse)
Modsite: DDAsATAsKtEtsQV SwissProt Entrez-Gene
Orthologous residues
Rhodopsin (human): S338‑p, Rhodopsin (mouse): S338‑p, Rhodopsin (rat): S338‑p, Rhodopsin (cow): S338‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  placental-retina
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (mouse)
KINASE GRK1 (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK1 (mouse) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
light increase
phorbol_ester no change compared to control