Curated Information
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Home > Curated Information Page > PubMed Id: 24189531
Warfel NA, et al. (2013) CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle 12, 3689-701 24189531
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S668-p - HIF1A (human)
Modsite: DTQSRTAsPNRAGkG SwissProt Entrez-Gene
Orthologous residues
HIF1A (human): S668‑p, HIF1A (mouse): S679‑p, HIF1A (rat): S668‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma
Relevant cell lines - cell types - tissues:  HCT116 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  cell growth, induced, cell motility, induced
Comments:  enhances invasion, angiogenesis, and tumor growth